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KMID : 0366220110460030200
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Korean Journal of Hematology
2011 Volume.46 No. 3 p.200 ~ p.202
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Clinical significance of anti-mitochondrial antibodies in a patient with chronic graft-versus-host disease following hematopoietic stem cell transplantation
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Lee Dong-Hyun
Huh Seok-Jae
Yoon Hyun-Hwa
Lee Sung-Wook
Kim Sung-Hyun
Kim Kyeong-Hee
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Abstract
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Recent studies indicate that patients with chronic graft-versus-host disease (GVHD) are not expected to show positivity for anti-mitochondrial antibody (AMA), which is a specific disease marker for primary biliary cirrhosis (PBC). A differential diagnosis between PBC and hepatic involvement of GVHD based on clinical manifestations and pathologic study is difficult because both diseases show similar results. Therefore, the presence of AMA may be important for distinguishing each disease. Here, we report a case of hepatic involvement of chronic GVHD with positive AMA, in which the pathologic findings and initial presentation of clinical findings were compatible with both PBC and chronic GVHD.
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KEYWORD
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Autoantibody, Anti-mitochondrial antibody, Chronic graft-versus-host disease, Hematopoietic stem cell transplantation
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